Overview

Cancer Models

Tissue Regeneration & Inflammation

Cytokines &
Growth Factors

Cadiovascular Disease

Technologies

Collaborations

 

 

 

 


Cancer Models

 

Alison Aiken
Shalini Anthwal
Virginie DeFamie
Marco DiGrappa
Iris Fang
Mehrdad Hariri
Carlo Hojilla
Hartland Jackson
Purna Joshi
Trevor McKee
Sam Molyneux
Geoffrey Wood

Breast – The mammary gland is a major area of our research.  We have acquired a considerable understanding of the role of specific genes in mammary morphogenesis, differentiation, involution and mammary tumorigenesis.  A current active area is how TIMPs function in defining the mammary stem cell niche.

Liver - We use liver regeneration to study how TIMPs regulate hepatocyte proliferation and apoptosis. Parallel studies in the CRP-TAg transgenic model allow us to determine how TIMP regulation of hepatocyte fate impacts hepatocellular carcinoma.

Lung – The role of the stromal compartment in lung cancer is being investigated in both genetic and orthotopic models of lung cancer. 

Prostate – Current mouse models of prostate cancer do not recapitulate the human disease, and we continue to attempt the development of novel models for this cancer.

Endometrial – PTEN heterozygous mice develop uterine hyperplasia and endometrial cancer. We are studying the role of specific genes on both breast and endometrial cancers.